Production of eurycomanone from cell suspension culture of Eurycoma longifolia
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چکیده
منابع مشابه
PRELIMINARY PHYTOCHEMICAL SCREENING OF EURYCOMANONE FOR Eurycoma longifolia
Eurycoma longifolia has been widely used in traditional herbal preparation and presently there are many commercial products available for general health and libido. However, study on plant breeding of this species is still in its infancy. Thus, Forest Research Institute Malaysia (FRIM) has taken an initiative to conduct provenance trial of this species in order to select the best provenance and...
متن کاملIsolation and lipolytic activity of eurycomanone and its epoxy derivative from Eurycoma longifolia.
Eurycomanone (1) and 13β,21-epoxyeurycomanone (2) were isolated from Eurycoma longifolia for studies of lipolytic activity. Compound 1 enhanced lipolysis in adipocytes with an EC50 of 14.6μM, while its epoxy derivate, compound 2, had a stronger activity with an EC50 of 8.6μM. Based on molecular mechanistic study using several specific inhibitors to lipolytic signaling pathways, it was found tha...
متن کاملEurycomanone and eurycomanol from Eurycoma longifolia Jack as regulators of signaling pathways involved in proliferation, cell death and inflammation.
Eurycomanone and eurycomanol are two quassinoids from the roots of Eurycoma longifolia Jack. The aim of this study was to assess the bioactivity of these compounds in Jurkat and K562 human leukemia cell models compared to peripheral blood mononuclear cells from healthy donors. Both eurycomanone and eurycomanol inhibited Jurkat and K562 cell viability and proliferation without affecting healthy ...
متن کاملInhibitory Effect of Eurycoma Longifolia Extract and Eurycomanone on Human Cytochrome P450 Isoforms
Objective: The aim of this study was to evaluate the inhibitory effect of E. longifolia extract on five human cytochrome P450 isoforms. Methods: The inhibitory effect of E. longifolia standardized extract (TAF-273) on five human cytochrome P450 isoforms, namely CYP1A2, CYP3A4, CYP2C9, CYP2C19 and CYP2D6, was determined using a luminescence method. The effect of eurycomanone on cytochrome P450 i...
متن کاملNF-κB Inhibitors from Eurycoma longifolia
The roots of Eurycoma longifolia have been used in many countries of Southeast Asia to alleviate various diseases including malaria, dysentery, sexual insufficiency, and rheumatism. Although numerous studies have reported the pharmacological properties of E. longifolia, the mode of action of the anti-inflammatory activity has not been elucidated. Bioguided isolation of NF-κB inhibitors using an...
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ژورنال
عنوان ژورنال: Pharmaceutical Biology
سال: 2017
ISSN: 1388-0209,1744-5116
DOI: 10.1080/13880209.2017.1400077